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Israel launched a new wave of strikes on Tehran on Sunday and Iran responded with more missile barrages, a day after the killing of Supreme Leader Ali Khamenei pitched the Middle East and the global economy into deepening uncertainty, Reuters reported. 

U.S. and Israeli strikes - and Iranian retaliation - sent shockwaves worldwide through sectors from shipping to air travel to oil, amid warnings of rising energy costs and disruption to business in the Gulf region.

The Israeli military said it had intercepted projectiles that were launched from Lebanon early Monday morning, in what could be the first sign of Lebanon's Shi'ite Muslim armed group Hezbollah, long one of Tehran's principal allies in the Middle East, entering the conflict, according to Reuters. 

The U.S. military announced on Sunday the first American casualties of President Donald Trump's intensifying attack on Iran, as a new poll showed only one in four Americans supported strikes against the Middle Eastern country, Reuters reported. 

As the conflict entered its second day, Trump said 48 Iranian leaders had been killed and that the U.S. military had started sinking Iran's Navy, destroying nine Iranian warships so far and "going after the rest."

U.S. aircraft and warships have struck more than 1,000 Iranian targets since Trump ordered the start to major combat operations on Saturday, the U.S. military said. The strikes include B-2 stealth bombers dropping 2,000-lb bombs on hardened, underground Iranian missile facilities, according to Reuters. 

Airlines are continuing to cancel and divert flights in the Middle East after the US and Israel launched strikes against Iran, BBC reported. 

Flights in and out of airports in Tel Aviv, Dubai, Doha and other international hubs in the region have been suspended. 

The UK Foreign Office is warning British citizens against all but essential travel to Bahrain, Kuwait, Qatar and the United Arab Emirates (UAE). Those already there have been advised to shelter.

Iran has launched attacks on the Gulf states as part its retaliation to US and Israeli strikes which began early on Saturday. Long-haul travel is being affected more widely, with Heathrow urging travellers to check with their airlines, according to BBC. 

Oman’s maritime security centre said the Palau-flagged oil tanker Skylight was attacked about five nautical miles off Musandam, said Aljazeera. Four people were wounded in the incident, and the vessel’s entire crew of 20 was evacuated.

Authorities said no further details are available about the nature of the attack or who may have been responsible. The condition of the injured crew members was not disclosed. The incident follows reports from Oman’s state media that two drones targeted the port of Duqm, injuring one foreign worker.